Use sumatriptan as soon as the migraine headache or cluster headache develops. It can make you feel tired or sleepy. If this happens, do not drive and do not use tools or machines. Your chest may feel tight or 'heavy' after taking sumatriptan. These sensations do not usually last for long, but if Treximet® (sumatriptan and naproxen sodium) is a selective 5-HT1B/1D receptor agonist and antiinflammatory indicated for the acute treatment of migraine, with or without aura, in adults and pediatric patients 12 years of age and older who have a clear migraine diagnosis. Initially, 6 mg subcutaneously. If headache symptoms return, a second 6 mg dose may be given with a minimum 1-hour interval between doses. Consider giving a second dose only if some response to the first dose was observed. ONZETRA ® Xsail ® is a prescription medication approved for the acute treatment of migraine, with or without aura in adults. ONZETRA Xsail is used for people who have been told by a healthcare provider that they have migraine headaches. The ONZETRA Xsail difference: Breath Powered ® delivery. How it works. ONZETRA allows you to control the delivery of your medication. The unique device uses the power of your own breath to deliver medicine directly to the back of your nose–it’s sumatriptan taken differently! User Reviews for Sumatriptan. Also known as: Imitrex, Imitrex Nasal, Onzetra Xsail. The following information is NOT intended to endorse drugs or recommend therapy. Imitrex (sumatriptan) is a selective serotonin receptor agonist used in oral, intranasal or injectable dosage form to treat migraine headaches. Imitrex is available as a generic drug. Imitrex Injection (sumatriptan succinate) is a selective serotonin receptor agonist used to treat migraine headaches. Imitrex is available as a generic drug. » Sumatriptan Nasal Spray is an aqueous, buffered solution of Sumatriptan. It is supplied in a form suitable for nasal administration. It contains not less than 90.0 percent and not more than 110.0 percent of the labeled amount of sumatriptan (C 14 H 21 N 3 O 2 S). Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.